Washington, Feb. 20.- A study suggests that conotoxins, present in the venom of the conus nux - a species of sea snail - could treat severe malaria, publishes the Journal of Proteomics.
According to the article, the research opens a new avenue for therapies against the most severe forms of the disease.
This is due to the persistence of cytoadhesion of infected erythrocytes, despite the fact that the parasites in the red blood cells are dead.
The conotoxins -afirman the experts have the ability to disrupt protein-protein interactions and protein-polysaccharide.
Molecular stability, small size, solubility, intravenous administration, and the absence of an immunogenic response make conotoxins excellent candidates for blocking therapy, the Journal of Proteomics publication detailed.
Likewise, the interruption of protein-protein interactions by conotoxins is an extension of their known inhibitory action on many ionic channels and receptors.
The World Health Organization applies the term severe malaria when there is a decreased level of consciousness, neurological signs, renal dysfunction, shock / hypotension, bleeding, disseminated intravascular coagulation, jaundice, pulmonary edema, hypoxia and acidosis. (PL)